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- W2390035562 abstract "Objective To study the PAI 1 gene expression of hepatic tissue and plasma PAI 1 activity in hyperlipidemia and fatty liver. Methods Rabbit model of hyperlipidemia and fatty liver were induced by high fat diet for 12 weeks, the plasma PAI 1 activity and hepatic PAI 1 mRNA expression were measured ( n =10) with colorimetry and RT PCR, another 7 rabbits were taken as normal control. Results Plasma PAI 1 activity increased in model group at 6 and 12 weeks, and was significantly higher than normal group at 12 weeks. PAI 1 mRNA relative values of hepatic tissue were also higher than normal group (3.474±0.051 vs 1.210±0.031, P 0.01). Conclusion Hepatic PAI 1 gene expression of rabbit with hyperlipidemia and fatty liver was increased, and could be the main cause of high plasma PAI 1." @default.
- W2390035562 created "2016-06-24" @default.
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- W2390035562 date "2000-01-01" @default.
- W2390035562 modified "2023-09-27" @default.
- W2390035562 title "Hepatic plasminogen activator inhibitor type 1 gene expression in rabbit with hyperlipidemia and fatty liver" @default.
- W2390035562 hasPublicationYear "2000" @default.
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