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- W2390044649 abstract "Objective To study the antitumor effect of peri-tumoral implantation of delayed-release PLGA-5-fluorouracil microsphere on colorectal tumor xenograft in mice.Methods Sixty tumor-bearing nude mice were randomly divided into six groups,group A and B were treated with peri-tumoral implantation of PLGA-5-fluorouracil microsphere,the doses of 5-fluorouracil were 200 mg/kg and 100 mg/kg respectively,group C and D treated with peri-tumoral injection of 5-fluorouracil solution,the doses of 5-fluorouracil were 200 mg/kg and 100 mg/kg,respectively,group E treated with PLGA microsphere,the dose was 800 mg/kg,group F did not receive any treatment.On the days of 0,3,6,9,12 and 15,health condition and body mass was weighed,the size of the tumor was observed.At the end of the experiment,the weight of the tumor was measured and tumor inhibition rate was calculated,the growth curve was drawn,blood were drawn for white cell count and liver,renal function test.Results The growth curves were mild in group A and B and sharp in group C,D,E and F.There were statistical differences of the tumor volume between group A,B and other groups,and there were no statistical differences of the tumor volume between group C,D,E and F.Tumor inhibition rates of group A and B were 75% and 62%,respectively.There were statistical differences between groups A,B and C,D.The weight change before and after treatment between group A,B,C,D,E and F had no statistical differences.White cell count,liver and renal function test were normal in all groups.Conclusion Delayed-release of PLGA-5-fluorouracil microsphere can effectively restrain the tumor growth and has no evidently side effects." @default.
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- W2390044649 date "2009-01-01" @default.
- W2390044649 modified "2023-09-23" @default.
- W2390044649 title "Effect of Delayed-Release PLGA-5-Fluorouracil Microsphere on Colorectal Cancer Xenograft in Nude Mice" @default.
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