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- W2390045230 abstract "Objective:To establish a HPLC method with a chiral mobile phase additive for the enantiomeric separation of ondansetron hydrochloride.Methods:The Hedera C18 column(250 mm×4.6 mm,5 μm)was used.The influences of type and concentration of sulfobutyl ether-β-cyclodextrin,buffer pH,the type and concentration of buffer,the type and ratio of organic phase and column temperature on the resolution of enantiomers were investigated.Results:The baseline separation of ondansetron hydrochloride enantiomers was achieved at 25 ℃ on the reversed-phase C18 column with a mobile phase of 10 mmol ·L-1 NaH2PO4(containing 5 mmol ·L-1 sulfobutyl ether-β-cyclodextrin,pH 3.0)-methanol(75 ∶25)at the flow rate of 1.0 mL ·min-1.Conclusion:Ondansetron hydrochloride enantiomers can be baseline-separated by this method which is simple and economic with good resolution." @default.
- W2390045230 created "2016-06-24" @default.
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- W2390045230 date "2011-01-01" @default.
- W2390045230 modified "2023-09-23" @default.
- W2390045230 title "Enantiomeric Separation of Ondansetron Hydrochloride by RP-HPLC Using Sulfobutyl Ether-β-cyclodextrin as a Chiral Additive" @default.
- W2390045230 hasPublicationYear "2011" @default.
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