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- W2390084630 abstract "Objective To detect the effect of PDTC(the selective inhibitor of NF-κB) combined with TNF-α on the growth and apoptosis of human cervical cancer HeLa cells,and the related mechanisms.Methods After treated by different doses of PDTC,TNF-α or combined with the two on human cervical cancer HeLa cells,MTT assay was used to measure the growth inhibition of HeLa cells.Light microscopy and DAPI method were used to observe the morphological changes and apoptosis.The protein expression of A20 and caspase-3 were detected by Western blot assay.Results PDTC(50,100 μmol/L) or TNF-α(30,60,120 mg/L) significantly inhibited the growth of HeLa cells.Low dose of PDTC(25 μmol/L) did not affect cell growth,however,its combination with TNF-α significantly increased the cell growth inhibition rate(P0.01) as compared with TNF-α.Cells appeared apoptotic morphological changes and the combination group increased the percentage of cell apoptosis(P0.01).In addition,TNF-α(60 mg/L) in combination with PDTC(25 μmol/L) group had no significant change in cytoplasmic protein A20,but increased the expression of caspase-3 protein(P0.05),compared with either TNF-α(60 mg/L)or PDTC(50 μmol/L) group.Co nclusions PDTC evidently enhances the cytotoxicity of TNF-α on cervical cancer cell line HeLa cells,which may be performed by inhibiting the activity of the TNF-α-induced nuclear transcription factor NF-κB and ultimately up-regulating of caspase-3 expression." @default.
- W2390084630 created "2016-06-24" @default.
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- W2390084630 date "2011-01-01" @default.
- W2390084630 modified "2023-09-28" @default.
- W2390084630 title "NF-κB inhibitor-PDTC enhance TNF-α induced cytotoxicity in human cervical cancer HeLa cells and its mechanism" @default.
- W2390084630 hasPublicationYear "2011" @default.
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