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- W2390090252 abstract "OBJECTIVE To systematically assess the efficacy and safety of probiotics for prevention of ventilator-associated pneumonia.METHODS Randomized controlled trials(RCTs)of probiotics for prevention of ventilator-associated pneumonia compared with placebo or other treatment were searched in PubMed,Web of Science,the Cochrane Library,CNKI,CBM and WanFang Data published before December 2012.RCTs were selected according to the inclusion and exclusion criteria.The data were extracted,the methodological quality of the included studies was assessed,and the Meta-analysis was performed with Revman5.1.0.RESULTS 9 RCTs on probiotics preventing ventilator-associated pneumonia(n=1243)were identified.The Meta-analyses showed that probiotics didn't statistically decease the incidence of VAP[RR=0.82,95%CI(0.66,1.01),P= 0.06]and other outcomes:ICU mortality[RR=0.88,95%CI(0.64,1.21),P=0.42],hospital mortality[RR=0.78,95%CI(0.58,1.05),P=0.10],ICU length of stay[MD=0.61,95%CI(-2.89,4.01),P=0.73],hospital length of stay[MD=-0.99,95%CI(-5.36,3.38),P=0.66],duration of mechanical ventilation days[MD=0.74,95%CI(-2.62,4.10),P= 0.67],incidence of diarrhea[RR=0.91,95%CI(0.77,1.09),P=0.31]and antibiotic-days.But the incidence of colonization of respiratory tract with Pseudomonas aeruginosa was statistically decease[RR=0.38,95%CI(0.15,0.94)P=0.04].No severe adverse events were found in all included studies.CONCLUSION The present evidence is not strong enough to prove that probiotics is effective to prevent VAP and reduce the mortality.However,the results of this Meta-analysis should be interpreted with caution because of the heterogeneity among study designs and ICU specialty.Large sample and high-quality randomized controlled trials are needed for further evaluation." @default.
- W2390090252 created "2016-06-24" @default.
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- W2390090252 date "2014-01-01" @default.
- W2390090252 modified "2023-09-23" @default.
- W2390090252 title "A systematic review and Meta-analysis on probiotics for prevention of ventilator-associated pneumonia" @default.
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