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- W2390101523 abstract "Objective:To observe the protective effects of Xuebijing on rat kidney and the expression of TGF-β1 and VEGF in kidney tissue of FSGS rats.Methods:Rat model of FSGS was established with unilateral nephrectomy and injection of Adriamycin caudal-venously.Rats were randomized into normal control group,Xuebijing-treated group,and model group.24 hours urinary protein and blood biochemical indicators were measured at the 0,4th,6th and 8th week.Creatinine clearance(Ccr) was calculated.Renal pathological changes were evaluated at the 8th week.Expression of TGF-β1 and VEGF were detected by immunohistochemical method.Results:Compared with that in the model group,24 hours urinary protein in Xuebijing-treated group was lower.The Pathological changes in Xuebijing-treated group were significantly improved compared with those in the model group.Compared with those in the normal control group,expressions of TGF-β1 and VEGF were increased in model group and Xuebijing-treated group;The expressions of TGF-β1 and VEGF in Xuebijing-treated group were significantly lower than those in the model group.Conclusion:Xuebijing can inhibit the high expression of TGF-β1and VEGF.It plays an important role in kidney protection on FSGS rats." @default.
- W2390101523 created "2016-06-24" @default.
- W2390101523 creator A5011256495 @default.
- W2390101523 date "2008-01-01" @default.
- W2390101523 modified "2023-09-23" @default.
- W2390101523 title "Experimental Study of Renoprotective Effect of Xuebijing in FSGS Rats" @default.
- W2390101523 hasPublicationYear "2008" @default.
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