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- W2390105675 abstract "Objective:To explore antihyperglycemic,antihyperlipidemic,antihypertensive and anti-tumor effects of the cactus fruit polysaccharide extract(CPFP).Method: The diabetic rats were induced by STZ in SD rats,and randomly divided into model group,insulin group(10 U·kg-1·d-1),high-dose group of CPFP(2.37 g·kg-1·d-1),low-dose group of CPFP(1.58 g·kg-1·d-1).The CPFP were administrated daily via gavage for eight weeks.During the experiment,the blood glucose of rats were determined.Male SD rats were fed by hyper-fatty diet for 3 weeks in order to establish the hyperlipemia rat model.The hyperlipemia rats were randomly divided into model group,lovastatin group(3.0 mg·kg-1·d-1),high-dose group of CPFP(2.37 g·kg-1·d-1),low-dose group of CPFP(1.19 g·kg-1·d-1).Different dose of CPFP were administrated daily via gavage for 3 weeks.The blood lipoprotein of rats were determined.Fifty male spontaneous hypertension rats(SHR)at the age of 15 weeks were randomly divided into model group,captopril group(0.01 g·kg-1·d-1),high-dose group of CPFP(2.37 g·kg-1·d-1),middle-dose group of CPFP(1.58 g·kg-1·d-1),low-dose group of CPFP(0.76 g·kg-1·d-1).Ten male Wistar rats were served as normal group.Different dose of CPFP were administrated daily via gavage for 9 weeks.The systolic blood pressure(SBP)of experimental rats was detected weekly.S180-tumor bearing mice were established and divided into model group,cyclophosphamide(CTX)group(0.02 g·kg-1·d-1),high-dose group of CPFP(1.97 g·kg-1·d-1),middle-dose group of CPFP(0.99 g·kg-1·d-1),low-dose group of CPFP(0.49 g·kg-1·d-1).The CPFP were administrated daily via gavage for 10 days.Tumor inhibition rates were recorded.Result: Compare with model group,the content of blood glucose was remarkably decreased and the hypoglycemic rates were 54.08% and 44.73% respectively in high-dose and low-dose group of CPFP.The levels of TC,TG and LDL-C were decreased significantly(P0.01)in high-dose and low-dose group of CPFP.The level of HDL-C was obviously increased in high dose group of CPFP(P0.05).The SBP level of SHR in CPFP treatment groups was depressed notability,nevertheless the SBP level of SHR of model group was increased obviously comparing with normal group after 9 weeks.The tumor was inhibited in CPFP treatment groups.The tumor inhibited rates were 49.70%,31.13 in high-dose,middle-dose group of CPFP respectively after 10 days.Conclusion:CPFP could markedly decrease blood glucose in STZ-induced diabetic rats and decrease blood lipoprotein in hyperlipemia rats.CPFP showed effects on reducing blood pressure in SHR and certain anti-tumor." @default.
- W2390105675 created "2016-06-24" @default.
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- W2390105675 date "2011-01-01" @default.
- W2390105675 modified "2023-09-23" @default.
- W2390105675 title "Pharmacodynamic Study on Cactus Fruit Polysaccharide Extract" @default.
- W2390105675 hasPublicationYear "2011" @default.
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