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- W2390111797 abstract "The alpha-fetoprotein(AFP) gene,a member of the albuminoid gene family,plays an important role in individual development.It is also a sign of hepatoma when its concentration is high in the adult.In order to study the polygenesis of AFP and the relationship between individual development and system development,the evolution of the albuminoid gene family was analyzed by analyzing the proteins of the gene family from different species by bioinformatics approaches,and drew a phylogenetic tree of different albumin domains from different proteins.Furthermore,the 14 kb intergenic space sequences were compared between ALB and AFP,including promoters,suppressors and enhancers in 5 different species. The evolution of AFP and its gene regulation mechanism from the point view of the system development were discussed.This research builds the theoretical basis to study the function of alpha-fetoprotein in physiology and pathology." @default.
- W2390111797 created "2016-06-24" @default.
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- W2390111797 date "2007-01-01" @default.
- W2390111797 modified "2023-09-23" @default.
- W2390111797 title "A bioinformatics analysis for the molecular evolution of alpha-fetoprotein" @default.
- W2390111797 hasPublicationYear "2007" @default.
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