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- W2390117070 abstract "Objective To investigate the effects of transforming growth factorβ1(TGF-β1)on the epithelial-tomesenchymal transition(EMT)in human tongue squamous cell carcinoma,and to explore its influence in PI3K/AKT signaling pathway.Methods The in vitro cultured tongue squamous cell carcinoma SCC9 cells and CAL27 cells were divided into control group and different concentrations(5and 10μg·L-1)of TGF-β1groups;24hafter TGF-β1 treatment,the morphology of cells in various groups were observed under light microscope.Immunoflurescence staining was used to detect the expressions of Vimentin and E-cadherin in the cells in various groups.The expressions of AKT and p-AKT in the SCC9 and CAL27cells were measured by Western blotting method.Results Compared with control group,the SCC9 and CAL27cells with polygonal morphology transdifferentiated into mesenchymal phenotype with an elongated morphology in TGF-β1groups.Compared with control group,the expressions of Vimentin protein in the cells in TGF-β1groups were increased and the expressions of E-cadherin were decreased.Compared with control group,the expression levels of p-AKT were decreased in SCC9 and CAL27cells in TGF-β1groups.Conclusion TGF-β1can induce the EMT in human tongue squamous cell carcinoma and affects the PI3K/AKT signaling pathway." @default.
- W2390117070 created "2016-06-24" @default.
- W2390117070 creator A5045287466 @default.
- W2390117070 date "2015-01-01" @default.
- W2390117070 modified "2023-09-28" @default.
- W2390117070 title "Induction effect of TGF-β1 on epithelial-to-mesenchymal transition of human tongue squamous cell carcinoma and its influence in PI3K/AKT signaling pathway" @default.
- W2390117070 hasPublicationYear "2015" @default.
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