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- W2390141573 abstract "[Purpose] To investigate the inhibitory effect of sorafenib combined with epirubicin (EPI) on the proliferation in breast cancer MCF-7 cells. [Methods] The growth curve of MCF-7 cells and cloning efficiency on 14th day was detected. The inhibitory effect of sorafenib,EPI and sorafenib+EPI treatment on MCF-7 proliferation in vitro was assessed by MTT assay at 72h. [Results] The growth curve showed that the growth velocity of MCF-7 cells was fast at the 1st~4th day,but slowed down after the 4th day,and stayed at a standstill after the 10th day. The cloning efficiency on 14th day of MCF-7 cells was 37.2%. Sorafenib and EPI both significantly inhibited the proliferation of MCF-7 cells at 72h, showing a synergistic effect of combination. [Conclusion] Sorafenib and EPI can inhibite the proliferation of MCF-7 cells. Sorafenib and EPI play a synergistic effect in inhibiting MCF-7 cells proliferation." @default.
- W2390141573 created "2016-06-24" @default.
- W2390141573 creator A5081452435 @default.
- W2390141573 date "2011-01-01" @default.
- W2390141573 modified "2023-09-28" @default.
- W2390141573 title "The Inhibitory Effect of Sorafenib Combined with Epirubicin on Proliferation in Breast Cancer MCF-7 Cells" @default.
- W2390141573 hasPublicationYear "2011" @default.
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