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- W2390145813 abstract "Objective:To observe the effects of Axin gene expression on the biological characteristics of glioma cells. Methods:The proliferation ability of transfected cells was examined by MTT assay, cell growth curve and colony formation assay. The change of cell cycle was analyses by flow cytometry (FCM).The apoptosis was measured by TUNEL staining. Immunostaining was used to detect the expression of Ki67, CyclinD1 and p53 in C6 cells and transfected cells. Results:The progression of the cell cycle was arrested in G1 phase after transfected with Axin plasmids; the cell viability, growing speed and colony formation ability were decreased significantly at the same time; the apoptotic rate increased, the expressions of Ki67 and CyclinD1 decreased, but the p53 level increased. Conclusion:Axin gene could inhibit C6 cell proliferation and arrest the transfected cells in G1 phase, and this biological effect might be depended on the increased expression of p53 and the decreased expression of CyclinD1. The molecular mechanism of Axin in cell proliferation needs more research." @default.
- W2390145813 created "2016-06-24" @default.
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- W2390145813 date "2006-01-01" @default.
- W2390145813 modified "2023-09-24" @default.
- W2390145813 title "Biological effects of Axin gene expression in glioma C6 cells" @default.
- W2390145813 hasPublicationYear "2006" @default.
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