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- W2390147170 abstract "OBJECTIVE To study the pharmacokinetics of gemcitabine and its metabolite in Chinese patients with malignant tumor. METHODS 8 patients were given a single of gemcitabine 1 000 mg·m-2 with infusing for 30 min.Serial plasma was obtained after completion of the infusion for determination of gemcitabine and dFdU concentrations. The gemcitabine and dFdU concentrations in plasma were measured using high-performane liquid chromatograpy (HPLC) .The pharmaeokinetic parameters were calculated by using PKS software. RESULTS The pharmacokinetics of both gemcitabine and dFdU fit biphasic kinetic models.The prarmeters of gemcitabine were ρmax (11.29±2.4)mg·L-1,t//2β(25.29±7.85)min,CL(7410±820)mL·min-1,Vd(270.13±53.36)L and AUC(2.23±0.34)mg·h·L-1) . While those of dFdU were ρmas(48.47±6.73)mg·L-1,t1/2β(8.04±3.66)h, CL( 102.98±24.8)mL·min-1,Vd(66.08±23.8)L and AUC (170.05±39.44)mg·h·L-1. CONCLUSION Pharmacokinetics of both gemcitabine and dFdU fit biphasic kinetic models. The pharmacoki-netic prarmeters of gemcitabine and its metabolite (dFdU) are similar comparison with that reported, except AUC and CL of gemeitabine, and the AUC, CL and t1/2 of gemcitabine are differences in gender." @default.
- W2390147170 created "2016-06-24" @default.
- W2390147170 creator A5030374112 @default.
- W2390147170 date "2005-01-01" @default.
- W2390147170 modified "2023-09-24" @default.
- W2390147170 title "Pharmacokinetics study of gemcitabine and its metabolite in Chinese patients with malignant tumor" @default.
- W2390147170 hasPublicationYear "2005" @default.
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