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- W2390152002 abstract "Objective To study apoptosis expression and its mechanism in lymphocytes and keratinocytes after focused ultrasound on guinea pig model of chronic eczema. Methods A total of 40 guinea pigs were shaved at two sites on the back.The eczema models were prepared by using 2, 4-dinitrochlorobenzene as an antigen to stimulate the shaved sites repeatedly and divided into 1W group and 2W group at random. The focused ultrasound treated one shaved site and the opposite site as the control without irradiation. Each group were observed at 24 h and 48 h after ultrasound irradiation. TUNEL was used to detect the distribution of apoptosis cells. The immunohistochemical method was used to detect the distribution of Bcl-2 and Bax protein in the skin tissues. Results Both the average percentage of apoptosis cells and Bax protein were higher in the treatment groups than in the control groups. The significant differentiation in Bcl-2 protein between the two groups was also observed.There was a positive correlated signification between apoptosis cells and Bax,and a negative correlation between apoptosis cells and Bcl-2. Conclusion Focused ultrasound can significantly induce the lymphocytes and keratinocytes of guinea pig model of chronic eczema to apoptosis and modulate the expression of the apoptosis related genes Bcl-2 and Bax." @default.
- W2390152002 created "2016-06-24" @default.
- W2390152002 creator A5086874263 @default.
- W2390152002 date "2008-01-01" @default.
- W2390152002 modified "2023-09-27" @default.
- W2390152002 title "Effect of focused ultrasound on the apoptosis of lymphocytes and keratinocytes in guinea pig model of chronic eczema" @default.
- W2390152002 hasPublicationYear "2008" @default.
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