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- W2390161755 abstract "Objective To investigate the changes of insulin resistance and its associated factors in normal and gestational hypertension pregnant women,determine the cause of disease and provide the basis for early clinical diagnosis and treatment. Methods The levels of blood lipid,glucose,insulin,human placental lactogen(HPL),estradiol(E2),nitric oxide(NO) and nitric oxide synthase(NOS) were detected by shexokinase method,radioimmunoassay and nitrate reductase etc respectively in 30 normal pregnant and 30 gestational hypertension cases. Results Fasting glucose and insulin levels did not change significantly in both groups with increasing gestational age(P 0. 05). Total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),HPL and E2 were significantly increased. The trimester of pregnancy were significantly higher than the indicators in early pregnancy(P 0. 05). Compared with normal group,there was no significant change in fasting blood glucose,but lower insulin,HDL-C,NO and NOS,and higher LDL-C in the pregnancy-induced hypertension cases(P 0. 05). In the gestational hypertension cases,at 16 weeks and 28 weeks of pregnancy,the levels of E2 were significantly higher than the normal group(P 0. 05),while the HPL levels in 28 weeks of pregnancy and childbirth was significantly lower than those in the normal group(P 0. 05). Conclusion Insulin resistance and the disruption of its associated factors take important roles in gestational hypertension which can be used as the potential biomarkers of diagnostic and therapeutic." @default.
- W2390161755 created "2016-06-24" @default.
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- W2390161755 date "2014-01-01" @default.
- W2390161755 modified "2023-09-24" @default.
- W2390161755 title "Values of Insulin Resistance,Placental Lactogen,Estradiol,NO and NOS in the Gestational Hypertension" @default.
- W2390161755 hasPublicationYear "2014" @default.
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