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- W2390171227 abstract "Objective To prepare the poly(D,L-lactic-co-glycolic acid)(PLGA)nanoparticles containing voriconazole and study their morpha and in vitro release.Methods The PLGA nanoparticles containing voriconazole were prepared by emulsion-solvent volatilization method,then observed for dispersity by laser light particle size analyzer,for morpha by scan electronic microscopy,and analyzed for drug-loading capacity and in vitro release by HPLC.Results The peak value and distribution index of nanoparticle size were(126±20)nm and 1.5 respectively.Under scan electronic microscope,the nanoparticles were distributed evenly,and their surfaces were smooth.The drug-loading capacity and envelopment rate of the nanoparticles were(1.9±0.6)% and 12% respectively.From the 2nd to the 8th day after observation,the voriconazole in nanoparticles were released slowly,though burst release was observed within 24 h.Conclusion The control-released PLGA nanoparticles containing voriconazole were successfully prepared,which may reduce the times of administration." @default.
- W2390171227 created "2016-06-24" @default.
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- W2390171227 date "2008-01-01" @default.
- W2390171227 modified "2023-09-25" @default.
- W2390171227 title "Preparation,Morpha and In Vitro Release of Poly(D,L-Lactic-co-glycolic Acid)Nanoparticles Containing Voriconazole" @default.
- W2390171227 hasPublicationYear "2008" @default.
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