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- W2390183396 abstract "Objective To investigate the inhibitory effect of genistein on the proliferation of human multiple myeloma(MM) cell and the expression of B-cell leukemia-lymphoma bcl-2,bcl-xl,cyclin D1,ICMA-1 gene expression and the change of expression of nuclear transcription factor(NF)-κB after treated the myeloma cell with genistein.Methods Human MM cell line XG1 cells were treated with varying doses of genistien.The effect of genistein on the proliferation of XG1 cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay.Gene expressions of bcl-2,bcl-xl,cyclin D1,ICMA-1 were measured by reverse transcriptase-polymerase chain reaction(RT-PCR).Intracellular expression of NF-κB was assayed by immunohistochemistry.Results The proliferation of XG1 cell decreased dose dependently after treated with genistein for 48 hours.Expressions of bcl-2,bcl-xl,cyclin D1 and ICMA-1 mRNA decreased in a dose dependant manner after treated with 5,10,15 μg/mL genistein.Genistein caused redistribution of NF-κB,with the expression of NF-κB in cytoplasm and decrease of NF-κB expression in nucleus.Conclusions Genistein inhibited the expressions of bcl-2,bcl-xl,cyclin D1,ICMA-1 mRNA via down-regulating the intranuclear expression of NF-κB,thereby inhibiting the proliferation,adhesion and metastasis of MM cells." @default.
- W2390183396 created "2016-06-24" @default.
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- W2390183396 date "2008-01-01" @default.
- W2390183396 modified "2023-09-28" @default.
- W2390183396 title "Inhibitory effect of genistein on the proliferation of multiple myeloma cell" @default.
- W2390183396 hasPublicationYear "2008" @default.
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