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- W2390188478 abstract "Objective To study the protective role of naloxone on brain cell of newborn with severe birth asphyxia.Methods 120 cases of newborn with severe asphyxia were randomly divided into two groups,both of them were given resuscitation and symptomatic treatment.Naloxone group(n=60) administrated with naloxone as soon as possible;control group(n=60) administrated with cerebrolysin and cytidine.Occurrence of seizure,degree of hypoxic ischemic encephalopathy(HIE),behavioral assessment and the level of serum endothine were observed to estimate the effect of treatment.Results The occurrence of seizure of repetitive seizure was significantly lower in naloxone group than control group (75.0%?vs?45.0%,χ 2=11.25,P0.01;33.33%?vs?69.77%,χ 2=12.71,P0.01);The percent that score less than 35 of behavioural assessment during 7-8 day and 12-14 day after birth was significantly lower in naloxone group than control group (53.70%?vs?81.40%,χ 2=8.18,P0.01;33.33%?vs?69.77%,χ 2=12.71,P0.01 respectively).The incidence of severe HIE was significantly lower in naloxone group than control group (40.00%?vs?61.67%,χ 2=5.63,P0.05),and the level of serum endothine was obviously decreased after 1 week treatment[(53.37%±8.26%)VS(81.27%±10.19%),t=14.46,P0.01)].Conclusion The administration of naloxone as soon as possible in newborn with severe asphyxia can increase cerebral blood flow,alleviate the degree both of cerebral edema and the brain injure caused by hypoxic-ischemic." @default.
- W2390188478 created "2016-06-24" @default.
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- W2390188478 date "2004-01-01" @default.
- W2390188478 modified "2023-09-28" @default.
- W2390188478 title "Protective role of Naloxone in brain cell of newborn with severe birth asphyxia" @default.
- W2390188478 hasPublicationYear "2004" @default.
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