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- W2390199587 abstract "Objective: To observe the clinical effects of local mild hypothermia therapy and its influence on the serum contents of nitricoxide, endothelin and intercellular adhesion molecule in patients with cerebral infarction, and to investigate its mechanisms of brain protection. Methods: 62 patients were randomly divided into the treatment(32 cases) and control groups. Drugs were used in both groups,and local mild hypothermia therapy was only applied in treatment groups. The recovery situation of nerve function defect was scored by NIHSS,Fugl Meyer Assessment Method and Bathel Index before and after treatment for 30 d. The serum contents of nitricoxide, endothelin and intercellular adhesion molecule were observed before and after treatment for 3,7 and 14 d. Results: Serum nitricoxide level of treatment group was higher than that of control group(P 0.01) on the 3rd,7th,14th day after onset. Serum endothelin level of treatment group was lower than that of control group(P0.01,P0.05) on the 3rd,7th,14th day after onset. Serum intercellular adhesion molecule level of treatment group was lower than that before the treatment on the 3rd,7th,14th day after onset,and on the 3rd,it was lower than that in control group(P0.05). There were not differences on NIHSS, Bathel index and Fugl Meyer assessment between the two groups(P0.05) before treatment. 1 month after therapy, NIHSS assessment of treatment group was lower than that of control group, while Bathel index and Fugl Meyer assessment of treatment group were higher than those of control group(P0.01). Conclusions: Local mild hypothermia therapy could protect vascular endothelial cell and improve the nerve function of patients with cerebral infarction." @default.
- W2390199587 created "2016-06-24" @default.
- W2390199587 creator A5061241001 @default.
- W2390199587 date "2013-01-01" @default.
- W2390199587 modified "2023-09-26" @default.
- W2390199587 title "Influence of Local Mild Hypothermia Therapy on the Serum Contents of Nitric Oxide, Endothelin and Intercellular Adhesion Molecule of Patients with Cerebral Infarction and its Clinical Signification" @default.
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