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- W2390206708 abstract "Objective To observe the antitumor effects of 17-a-D-homo ethynyclestradiol-3-accetate(DHEA) combined with radiotherapy or chemotherapy and protective effect of DHEA on hematopoietic function in tumor-bearing nude mice. Methods EC109 cell suspension were vaccinated by 0.1 mL per mouse right armpit, the day of the first vaccination was selected to day1. The EC109-inoculated nude mice of 30 were divided into six treatment groups as control, irradiation, fluorouracil(5-Fu),DHEA, DHEA combined with irradiation and DHEA combined with 5-Fu. The groups with DHEA were continuously delivered drugs for 9 days, with 0.2 mL/each,1 time/d, the groups with 5-Fu were injected in fourth and eighth day, the group with irradiation were given 2 Gy twice. 5- Fu intraperitoneal were injected in accordance with the dose of 25 mg/kg, 0.2 mL/each, day 1, a total of dosing was four times. the tumor inhibition rate, the number of peripheral blood cells, bone marrow nucleated cell count were detected after 12 d. Results The results showed that tumor weight in DHEA [(0.34±0.02) g], DHEA combined with irradiation [(0.30±0.02) g] or 5-Fu [(0.23±0.02) g] mice were all significantly lower than those of control group[(0.90±0.02) g](P 0.01); the tumor weight in DHEA combined with irradiation group [(0.30±0.02) g] was lower than that of irradiation group [(0.70±0.03) g](P 0.05). The BMNC cells in DHEA [(18.3±1.7) ×106], DHEA combined with irradiation[(19.3±0.5) ×106] or 5-Fu [(19.2±2.0) ×106] group were all significantly higher than those of irradiated group [(9.4±2.4) ×106](P 0.05). Conclusion DHEA combined with irradiation or 5-Fu shows synergic effect on EC109-inoculated nude mice and protectes hematopoietic system from irradiation injury." @default.
- W2390206708 created "2016-06-24" @default.
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- W2390206708 date "2013-01-01" @default.
- W2390206708 modified "2023-09-23" @default.
- W2390206708 title "The antitumor effects of DHEA combined with radiotherapy and chemotherapy on human esophageal transplanted carcinoma in nude mice" @default.
- W2390206708 hasPublicationYear "2013" @default.
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