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- W2390225049 abstract "Objective To study the imaging signs and the pathological basis of early avascular necrosis of the femoral head (ANFH) in animal models.Materials and Methods ANFH model was prepared in 18 healthy naturally bred goats, regardless of the sex and age. The un operated femoral heads were taken as control group. MRI CT and radiography were performed at 1, 2, 3, 4, 5, 7 and 12 weeks after the procedure. The animals were sacrificed immediately after the last examination. Both femoral heads were removed and macroscopic and microscopic observations were made.Results No abnormal findings were seen on CT and radiographs in 7 weeks after the procedure. In experimental group at 12 weeks, decreased density was seen in one of 3 femoral heads on radiographs, while in all 3 heads on CT scans. MRI demonstrated abnormal signal in 6 of 9 heads during the first week. During 3～12 weeks, abnormal MR signals were seen in all diseased heads. Before 12 weeks, no any change in shape was found in all imaging examinations. Pathologically, focal dissolution of the marrow, cell fragments in bone trabeculae, granulation, or liquefaction of the fat occurred within 1～2 weeks. Marrow necrosis kept going with fibrous hyperplasia during 3～7 weeks until 12 weeks when the necrosis stopped and the new bone formation occurred. MRI was the most sensitive technique in detecting early changes of ANFH.Conclusion In this experiment, the radiography and CT can not demonstrate the early pathologic changes of ANFH within 7 weeks after the surgery. Only after 12 weeks, slight decreased bone density and trabecular derangement due to marrow necrosis and decalcification can be observed. Thus, radiography and CT is of little value in detecting early changes of ANFH. In contrast, MRI is very sensitive, the abnormal signals can be detected as early as in the first week, thus, MRI is of the choice for early ANFH." @default.
- W2390225049 created "2016-06-24" @default.
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- W2390225049 date "2002-01-01" @default.
- W2390225049 modified "2023-09-23" @default.
- W2390225049 title "The Imaging Pattern of Early Avascular Necrosis of the Femoral Head: An Experimental Study" @default.
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