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- W2390225908 abstract "Utilizing cocultures ofmouserenal juxtaglomerular cells with bovine microvascular endothelial cells, wehaveexamined whether endothelial cells exert direct influence onrenin secretion fromrenal juxtaglomerular cells. Inthepresence ofendothelial cells bothspontaneous and forskolin (10isM) orisoproterenol (10sM)stimulated renin release weremarkedly attenuated. Thestimulatory effect ofthe calmodulin antagonist calmidazolium (10pM)onrenin secretion wasnotaltered byendothelial cells, whereas thestimulatoryeffect ofethylisopropylamiloride (50pM)aninhibitor of sodium-proton exchange wasenhanced inthepresence ofendothelial cells. Indomethacin (101M)andNG-monomethyl-l-arginine (NMMA)(1mM)usedtoinhibit cyclooxygenase activityandproduction ofendothelium-derived relaxing factor (EDRF)decreased spontaneous renin release inthepresence of endothelial cells only, buthadnoeffect onforskolin stimulated renin secretion. Endothelin (1pM)inhibited cAMPstimulated renin release bothintheabsence andinthepresence ofendothelial cells. ATP(10pM)whichactsonbothendothelial and juxtaglomerular cells viapurinergic P2receptors inhibited cAMPstimulated renin release onlyintheabsence butnotin thepresence ofendothelial cells. Thismodulatory effect ofendothelial cells wasnoaltered byindomethacin norbyNMMA. Takentogether, ourfindings provide first evidence fora local control function oftheendothelium oncAMPstimulated renin secretion fromrenal juxtaglomerular cells, which could in partbemediated byendothelin. (J.Clin. Invest. 1991. 88:1147-1154.) Keywords: cyclic AMP *ATP*endothelino EDRF-prostacyclin" @default.
- W2390225908 created "2016-06-24" @default.
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- W2390225908 date "1991-01-01" @default.
- W2390225908 modified "2023-09-27" @default.
- W2390225908 title "Endothelial CellsModulateReninSecretion from Isolated MouseJuxtaglomerular Cells" @default.
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