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- W2390242562 abstract "Objective:To investigate the intervention of amlodipine combined with composite salviae dropping pill on vascular remodeling of spontaneously hypertensive rats. Methods:32 SHRs were randomly divided into 4 groups with 8 SHRs each. Some indexes of the blank contrast group (SHR_C) were detected with any treatment and compared with those of 8 Wistar rats. The negative contrast group (SHR_ NS), the positive group (SHR_A) and the treatment group (SHR_ A+D) were injected by sodium chloride, amlodipine, and amlodipine combined with composite salviae dropping pill respectively. After 8 week treatment, all rats were executed and indexes detected. Results:Compared with those of Wistar rats, the blood pressure, lumen of blood vessel, thickness of vascular wall of SHR_C and SHR_ NS increased obviously. Especially VSMC became hypertrophy. After treatment, the blood pressure of SHR_A and SHR_ A+D significantly decreased. The thickness of vascular wall was also restrained. The vascular wall of SHR_A was thinner than that of SHR_ A+D. The difference had no statistic meaning. Conclusion:Amlodipine can restrain vascular remodeling by decreasing the blood pressure. The additional composite salviae dropping pill have the further intervention function, which maybe show the time-benefit relation." @default.
- W2390242562 created "2016-06-24" @default.
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- W2390242562 date "2006-01-01" @default.
- W2390242562 modified "2023-09-27" @default.
- W2390242562 title "Intervention of Amlodipine Combined with Composite Salviae Dropping Pill on Vascular Remodeling of Spontaneously Hypertensive Rats" @default.
- W2390242562 hasPublicationYear "2006" @default.
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