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- W2390258045 abstract "OBJECTIVE To prepare nanoparticles of irinotecan hydrochloride(CPT-11 NPS)and to evaluate their particle size,morphology,encapsulation efficiency and release characteristics.METHODS CPT-11 NPS were prepared by precipitation.The encapsulated ratio was used as an estimated parameter in order to select one of the most appropriate formulations The morphology of CPT-11 NPS was characterized by transmission electron microscopy.The particle size was measured by laser granularity analyzer.The encapsulation efficiency was determined by Sephadex G-50 gel chromatography.Dialysis was applied to investigate the release of CPT-11 NPS.RESULTS The prepared CPT-11 NPS were spherical with intensity diameter of(193.5±2.5) nm.The drug loading capacity and encapsulation efficiency were 26.35% and(98±0.01)%,respectively.The cumulative release amount reached 62.09% of CPT-11 NPS during 24 h,and CPT-11 NPS released CPT-11much more slowly compared with aqueous irinotecan hydrochloride solution.CONCLUSION The particle size of the CPT-11 NPS prepared by the use of this optimized formulation is uniform,the encapsulation efficiency is high and CPT-11 NPS have extended-release features." @default.
- W2390258045 created "2016-06-24" @default.
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- W2390258045 date "2012-01-01" @default.
- W2390258045 modified "2023-09-26" @default.
- W2390258045 title "Preparation and in vitro evaluation of nanoparticles of irinotecan hydrochloride" @default.
- W2390258045 hasPublicationYear "2012" @default.
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