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- W2390259311 abstract "Objective To investigate the effects of mitogen-activated protein kinase p38(p38 MAPK)on CD3/CD28-stimulated T-cell proliferation and IL-2 expression which were enhanced by shockwaves.Methods Jurkat T cells or peripheral blood mononuclear cells(PBMC)were pretreated with the p38 MAPK-inhibitor(SB203580)(The Jurkat T cells or PBMC of the control groups were not pretreated with SB203580),then treated with shockwaves,and stimulated respectively with a suboptimal dose of anti-CD3 and anti-CD28 antibodies or PHA.Finally the IL-2 productions of Jurkat T cells or the proliferation of PBMC were respectively measured.The protein tyrosine phosphorylation of p38 MAPKin Jurkat T cells treated either with shockwaves or not was measured by Western blotting with anti-phosphotyrine antibodies(Thr180/Tyr182).The expressoins of p38 MAPK in Jurkat T cells treated either with shockwaves or not were determined by Western blotting with anti-p38 MAPK antibodies.Results Compared with negative control group without shockwave treatment,the 3H-TdR incorporation of the phytohemagglutinin-stimulated PBMC,which were treated with low dose shockwaves(LDSWs)of 100,150,200,250,300,330 impulses at(0.180±0.015)mJ·mm2,increased significantly(P0.01).Compared with negative control group,the additions of SB203580 attenuated the IL-2 expression in the cellular supernatant of CD3/CD28-stimulated Jurkat T cells or the 3H-TdR incorporation of the phytohemagglutinin-stimulated PBMC,which were affected with LDSWs of 100,150,200,250,300,330 impulses at(0.18±0.015)mJ·mm2(P0.01).The activation of p38 MAPK under the condition without LDSWs was obviously lower than that with LDSWs of 100,150,200,and 250 impulses(P0.01),and the activation of p38 MAPK increased with the shock-wave impulses.Conclusion SB203580 prevents the enhancing effect of LDSWs on CD3/CD28-stimulated IL-2 expression.In T cells,the shockwaves enhance IL-2 expression through activating p38 MAPK." @default.
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- W2390259311 date "2007-01-01" @default.
- W2390259311 modified "2023-09-23" @default.
- W2390259311 title "Effects of mitogen-activated protein kinase p38 on CD3/CD28-stimulated T-cell proliferation and IL-2 expression enhauced by shockwaves" @default.
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