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- W2390259724 abstract "Objective To study the antitumor effect of MIP-1α and B7-1 gene transfection on mouse lymphoma.Methods Mouse lymphoma EL-4 cells were transfected by lentivirus-mediated mouse MIP-1α and B7-1 gene vectors.MIP-1α and B7-1 mRNA were identified by RT-PCR,and MIP-1α and B7-1 proteins were determined by Western blot.The transfected EL-4 cells were injected into the right axilla in mice to induce tumor growth.The transfected EL-4 cells were inactivated and injected into tumor-bearing mice to observe their antitumor effect.Results RT-PCR assay showed expressions of MIP-1α and B7-1 mRNA in the EL-4/MIP-1α+B7-1 cells,and Western blot revealed expression of MIP-1α and B7-1 proteins.The tumor formation was retarded,tumor formation rate was decreased,and the tumor was smaller in the MIP-1α group and B7-1 group than that in the control group,and no tumor was formed in the MIP-1α+B7-1 group.The mean tumor volume,weight and organ metastasis rate of the MIP-1 α and B7-1 groups were significantly lower than that of the control group(P0.05),while the mean tumor volume and weight of the MIP-1α+B7-1 group were significantly lower than that of the MIP-1α group and B7-1 group(P0.05).In addition,the mean survival time of the MIP-1α+ B7-1 group was significantly longer than that in the single groups and the control group(P0.05).Conclusions Lentivirus-mediated mouse MIP-1α and B7-1 gene transfection can effectively enhance the anti-lymphoma effect on tumor-bearing mice,and can significantly prolong the mean survival time of tumor-bearing mice.It may provide a new idea for gene therapy of lymphoma in future." @default.
- W2390259724 created "2016-06-24" @default.
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- W2390259724 date "2013-01-01" @default.
- W2390259724 modified "2023-09-27" @default.
- W2390259724 title "Inhibitory effect of MIP-1α and B7-1 gene transfection on mouse lymphoma" @default.
- W2390259724 hasPublicationYear "2013" @default.
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