Matches in SemOpenAlex for { <https://semopenalex.org/work/W2390269324> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2390269324 endingPage "557" @default.
- W2390269324 startingPage "555" @default.
- W2390269324 abstract "The effect of coadministration of an antacid on bioavailability of a sustained-release theophylline tablet preparation (Theo-Dur) was studied by crossover comparison in five young, healthy, nonsmoking volunteers. Water 90 ml, or “high potency” aluminum-magnesium hydroxide antacid (Mylanta II) 10 ml and water 80 ml were administered concurrently with sustained-release theophylline 600 mg. Eleven blood samples were collected over the next 24 hours. Serum was analyzed with high pressure liquid chromatography technique to determine theophylline concentration. Peak serum concentration (C max ) and time to peak concentration (t max ) were determined, and area under the 24-hour serum concentration-time curve (AUC) was calculated by the trapezoidal rule for each subject at each study interval. The Student's paired t-test was used to compare C max , t max , and AUC for both treatments. A uniform difference was found between groups in C max . C max was higher in subjects when treated with the antacid (10.45 ± 3.03 vs. 8.30 ± 2.90 μg/ml, p < 0.05) than when given theophylline alone. The mean t max for the two treatments did not differ (10.4 ± 1.67 h—combination vs. 10.8 ± 1.1 h—theophylline, p > 0.05). Likewise, mean AUC was unchanged by the coadministration of antacid (140.65 ± 41.6 μg/ml·h—combination vs. 155.13 ± 46.6 μg/ml·h—theophylline, p > 0.05). The use of a high-potency antacid product did not decrease the extent of theophylline absorption from this sustained-release product, but did increase C max and, presumably, rate of absorption. High-potency aluminum-magnesium antacids can probably be used in combination with this sustained-release theophylline tablet without detriment to therapy." @default.
- W2390269324 created "2016-06-24" @default.
- W2390269324 creator A5011018459 @default.
- W2390269324 creator A5029692083 @default.
- W2390269324 creator A5047202751 @default.
- W2390269324 creator A5048965197 @default.
- W2390269324 date "1983-07-01" @default.
- W2390269324 modified "2023-09-26" @default.
- W2390269324 title "Effect of Antacid on Bioavailability of a Sustained-Release Theophylline Preparation" @default.
- W2390269324 cites W1886116833 @default.
- W2390269324 cites W1989414638 @default.
- W2390269324 cites W2043051886 @default.
- W2390269324 cites W2051594974 @default.
- W2390269324 cites W2300079107 @default.
- W2390269324 cites W2410974324 @default.
- W2390269324 cites W2725188872 @default.
- W2390269324 doi "https://doi.org/10.1177/106002808301700717" @default.
- W2390269324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6872853" @default.
- W2390269324 hasPublicationYear "1983" @default.
- W2390269324 type Work @default.
- W2390269324 sameAs 2390269324 @default.
- W2390269324 citedByCount "7" @default.
- W2390269324 crossrefType "journal-article" @default.
- W2390269324 hasAuthorship W2390269324A5011018459 @default.
- W2390269324 hasAuthorship W2390269324A5029692083 @default.
- W2390269324 hasAuthorship W2390269324A5047202751 @default.
- W2390269324 hasAuthorship W2390269324A5048965197 @default.
- W2390269324 hasConcept C125287762 @default.
- W2390269324 hasConcept C126322002 @default.
- W2390269324 hasConcept C142724271 @default.
- W2390269324 hasConcept C159985019 @default.
- W2390269324 hasConcept C181389837 @default.
- W2390269324 hasConcept C185592680 @default.
- W2390269324 hasConcept C192562407 @default.
- W2390269324 hasConcept C202751555 @default.
- W2390269324 hasConcept C204787440 @default.
- W2390269324 hasConcept C27081682 @default.
- W2390269324 hasConcept C2776042228 @default.
- W2390269324 hasConcept C2776768635 @default.
- W2390269324 hasConcept C2778095195 @default.
- W2390269324 hasConcept C2780590083 @default.
- W2390269324 hasConcept C2781018748 @default.
- W2390269324 hasConcept C43617362 @default.
- W2390269324 hasConcept C55493867 @default.
- W2390269324 hasConcept C57992300 @default.
- W2390269324 hasConcept C6557445 @default.
- W2390269324 hasConcept C71924100 @default.
- W2390269324 hasConcept C76318530 @default.
- W2390269324 hasConcept C86803240 @default.
- W2390269324 hasConcept C87813604 @default.
- W2390269324 hasConcept C98274493 @default.
- W2390269324 hasConceptScore W2390269324C125287762 @default.
- W2390269324 hasConceptScore W2390269324C126322002 @default.
- W2390269324 hasConceptScore W2390269324C142724271 @default.
- W2390269324 hasConceptScore W2390269324C159985019 @default.
- W2390269324 hasConceptScore W2390269324C181389837 @default.
- W2390269324 hasConceptScore W2390269324C185592680 @default.
- W2390269324 hasConceptScore W2390269324C192562407 @default.
- W2390269324 hasConceptScore W2390269324C202751555 @default.
- W2390269324 hasConceptScore W2390269324C204787440 @default.
- W2390269324 hasConceptScore W2390269324C27081682 @default.
- W2390269324 hasConceptScore W2390269324C2776042228 @default.
- W2390269324 hasConceptScore W2390269324C2776768635 @default.
- W2390269324 hasConceptScore W2390269324C2778095195 @default.
- W2390269324 hasConceptScore W2390269324C2780590083 @default.
- W2390269324 hasConceptScore W2390269324C2781018748 @default.
- W2390269324 hasConceptScore W2390269324C43617362 @default.
- W2390269324 hasConceptScore W2390269324C55493867 @default.
- W2390269324 hasConceptScore W2390269324C57992300 @default.
- W2390269324 hasConceptScore W2390269324C6557445 @default.
- W2390269324 hasConceptScore W2390269324C71924100 @default.
- W2390269324 hasConceptScore W2390269324C76318530 @default.
- W2390269324 hasConceptScore W2390269324C86803240 @default.
- W2390269324 hasConceptScore W2390269324C87813604 @default.
- W2390269324 hasConceptScore W2390269324C98274493 @default.
- W2390269324 hasIssue "7-8" @default.
- W2390269324 hasLocation W23902693241 @default.
- W2390269324 hasLocation W23902693242 @default.
- W2390269324 hasOpenAccess W2390269324 @default.
- W2390269324 hasPrimaryLocation W23902693241 @default.
- W2390269324 hasRelatedWork W1980571189 @default.
- W2390269324 hasRelatedWork W2058698877 @default.
- W2390269324 hasRelatedWork W2064803923 @default.
- W2390269324 hasRelatedWork W2083610014 @default.
- W2390269324 hasRelatedWork W2107947371 @default.
- W2390269324 hasRelatedWork W2390269324 @default.
- W2390269324 hasRelatedWork W2404895569 @default.
- W2390269324 hasRelatedWork W2419272372 @default.
- W2390269324 hasRelatedWork W2474355725 @default.
- W2390269324 hasRelatedWork W46633649 @default.
- W2390269324 hasVolume "17" @default.
- W2390269324 isParatext "false" @default.
- W2390269324 isRetracted "false" @default.
- W2390269324 magId "2390269324" @default.
- W2390269324 workType "article" @default.