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- W2390269841 abstract "Objective To investigate the profile of chemokine (ChKs) expression in viral myocarditis (VMC) induced by coxsackievirus group B type 3 (CVB3) and to discuss its implications in pathogenesis of VMC. Methods BALB/c mice were inoculated intraperitoneally with CVB3 to establish animal model of VMC. The expression of 12 ChKs including MIP-2, MIG, IP-10, BLC (CXC family), MCP-1, MIP-1β, RANTES, MCP-2, Eotaxin, LARC (CC family), Ltn (C family) and FKN (CX3C family) was qualitatively and quantitatively detected by RT-PCR. Histological changes of VMC were evaluated by hematoxylin and eosin staining, and severity of myocardial injury was determined by detection of serum CK-MB. Results (1) A total of 9 ChKs were detectable in the myocardial tissue of VMC mice, whereas only 6 ChKs were found in normal control. Three ChKs (BLC, Eot and LARC) were not detected in VMC group nor in normal control. (2) 3 out of 9 ChKs (MIP-2, MIG and IP-10) were inducible in VMC group and the others were constitutive. Among the constitutively expressed ChKs, 4 of them including MIP-1β, MCP-1, MCP-2 and Ltn were up-regulated, whereas the RANTES were down-regulated. There was no significant difference between VMC and normal in expression of FKN. (3) Compared with the normal control, the expression patterns of ChKs varied from one to another at different time points in VMC mice. The highest expression level of MIP-2 was found at 4 days after infection and then the expression decreased continuously. The expression of both MCP-1 and RANTES climbed up to a peak after 9 days of infection, while the expression of FKN remained stable within 9 days. (4) The expression profile of the ChKs examined in this study was significantly different among the early, middle and middle-late as well as late stage of VMC, but the dominant ChKs in VMC could be elucidated, i. e. IP-10 dominantly expressed in the early and middle stage of VMC, whereas MCP-1 in the middle-late and late stage. Conclusions The expression of ChKs in myocardial tissue vary significantly in clusters, while complexity of these changes was consistent with that of pathogenesis in VMC. The dominantly expressed ChKs may play a much more important role in pathogenesis of VMC. [" @default.
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- W2390269841 date "2003-01-01" @default.
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- W2390269841 title "Chemokine expression profile and its implications in viral myocarditis" @default.
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