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• W2390286791 abstract "Objective To compare the efficacy and safety of prophylactic enteral probiotics administration versus placebo or no treatment in the prevention of severe NEC and sepsis in preterm infants.Methods Standard search strategy for the Cochrane Neonatal Review Group was performed by two review authors.Searches were made in PubMed,EMBASE,Ovid,Springer and CNKI databases with the terms Preterm or newborn or infants or very low birth weight or extremely low birth weight and probiotics or lactobacillus or bifidobactrium or saccharomyces and necrosis enterocolitis.Only randomized or quasi-randomized controlled trials which involved enteral administration of any live microbial supplement(probiotics) and measured at least one prespecified clinical outcome such as morbidity of severe NEC,sepsis or mortality were considered.Standard methods of the Cochrane Collaboration and its Neonatal Group were used to assess the methodological quality of the trials.RevMan 4.22 software was used to make meta analysis.Results 107 literatures were reviewed.The studies including full-term infants RCTs(n=52),reviews(n=17),commentators(n=4),documents not meeting the major results of the meta analysis(n=15),case-control studies(n=3),self-control studies(n=2),not randomized studies(n=2),data undetailed and to contact the author unsuccessfully studies(n=10) were excluded.Ten eligible trials randomizing 2 117 infants(1 056 of treatment group and 1 061 of control group) were included.The results of quality assessment were that 8 studies were A,1 was B and 1 was C.Included trials were highly variable with regard to enrollment criteria such as birth weight and gestational age,baseline risk of NEC in the control group,timing,dose,formulation of the probiotics,and feeding regimens.Data regarding extremely low birth weight(ELBW) infants were few.In a meta analysis of trial data,enteral probiotics supplementation significantly reduced the incidence of severe NEC(stage Ⅱ or above)(OR=0.34,95%CI:0.22-0.55) and mortality(OR=0.36,95% CI:0.22-0.58).There was no evidence on significant incidence reduction in nosocomial sepsis(OR=0.94,95%CI:0.62-1.42) or in NEC-related deaths(OR=0.48,95%CI:0.16-1.47).The hospilized days were longer in treatment group than that in control group(P0.01).The included trials were reported no systemic infection with the probiotics supplemental organism.Conclusions Enteral supplementation of probiotics reduced the risk of severe NEC and mortality in preterm infants.This analysis supports a change in practice in premature infants 1 000 g at birth.The safety and efficacy of administration of probiotic supplements couldn't be made in ELBW.A large randomized controlled trial is required to investigate the potential benefits and safety profile of probiotics supplementation in ELBW infants." @default.
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• W2390286791 date "2009-01-01" @default.
• W2390286791 modified "2023-09-23" @default.
• W2390286791 title "The effect of oral probiotics on the prevention of necrotizing enterocolitis in preterm infants:a meta-analysis of its efficacy and safety" @default.
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