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- W2390289058 abstract "Objective To determine the proliferation inhibition activity of Jiuwei-Tongqiao soup on human glioma cells and analyze its chemical constituents.Methods The ethanol extract from Jiuwei-Tongqiao soup and its single medicinal materials were collected by reflux extraction using 95% ethanol.MTT colorimetry assay was performed to evaluate the proliferation inhibition activity of the ethanol extract from Jiuwei-Tongqiao soup on human glioma cells U251 in vitro,the fi ngerprints were detected by HPLC-MS and the structures of major components were confirmed in comparison with the reference substances.Results The proliferation of U251 cells was inhibited markedly in vitro by the ethanol extract from Jiuwei-Tongqiao soup.The dose response curve of MTT colorimetry assay is Y=0.123X+0.034 5,the median inhibitory concentration IC50 after 24h is 3.78g/L and the safe concentration IC10 after 24h is 0.53g/L.The fingerprint of Jiuwei-Tongqiao soup has 28 peaks and contains quercetin,calycosin,calycosin-7-glucoside(calycosin-7-O-β-D-glucoside),formononetin,and ononin(formononetin-7-O-β-D-glucoside) which belong to the monarch herba Astragalus mongholicus and Oldenlandia diffusa.Conclusion The ethanol extract from Jiuwei-Tongqiao soup has antiglioma activity in vitro.The fingerprint can be determined rapidly,conveniently and accurately by HPLC-MS and demonstrated good correlation with the fi ngerprints of the monarch harba and its structures of major components can be confi rmed in comparison with the reference substances.It lays the foundation of researching the structure of Jiuwei-Tongqiao soup's effective components in future." @default.
- W2390289058 created "2016-06-24" @default.
- W2390289058 creator A5043374824 @default.
- W2390289058 date "2014-01-01" @default.
- W2390289058 modified "2023-09-24" @default.
- W2390289058 title "Determination of the Inhibition Activity of Jiuwei-Tongqiao Soup on Brain Glioma in vitro and Analysis of Its Chemical Constituents" @default.
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