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- W2390300265 abstract "Objective To investigate the effect of the aqueous extract of loquat flower( AELF) on acute alcoholic liver injury in mice. Methods The mice were randomly divided into 6 groups: control group,model group, positive drug group( Bifendate),and AELF groups at different doses( 400,800,1600 mg·kg- 1). Each group has 10 mice. Drugs were given once a day for 10 consecutive days,0. 10 ml /10 g a time. 50%( V / V) dehydrated alcohol of 0. 12 ml /10 g was fed orally 2 h after the last administration except in control group. Then the animals were fasted for 16 h with water drinking allowed. Results Compared with model group,the AELF group at the dose of 800 mg·kg- 1underwent a marked decrease in the level of aspartate amino transferase( AST),triglyceride( TG) of the serum and liver( P 0. 01,P 0. 01,P 0. 05) and the amount of WBC returned to normal( P 0. 01), while in the 1600 mg·kg- 1group the level of alanine amino transferase( ALT) in serum and the concentration of malondialdehyde( MDA) in liver homogenates was reduced significantly( P 0. 01,P 0. 05). Conclusion AELF can lower the level of ALT,AST,TG and improve the anti-oxidation ability of organisms. It has proactively protective effect on acute alcohol-induced liver injury in mice." @default.
- W2390300265 created "2016-06-24" @default.
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- W2390300265 date "2014-01-01" @default.
- W2390300265 modified "2023-09-28" @default.
- W2390300265 title "Protective Effect of Aqueous Extract of Loquat Flower on Acute Alcohol-induced Liver Injury in Mice" @default.
- W2390300265 hasPublicationYear "2014" @default.
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