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- W2390315322 abstract "【Objective】The aim of this study was to locate Follicle-stimulating hormone receptor(FSHR)and Luteinizing hormone receptor(LHR)LHR in hypothalamus oviduct,and determine whether Lipopolysaccharide(LPS)impact on the expression of FSHR and LHR in hypothalamus and oviduct.【Method】36mature New Zealand female rabbits were divided into 9groups(n=4),one group non-treatment and worked as 0hgroup,LPS group injected with LPS(0.5mg/kg)or saline(control).The hypothalamus and oviduct were collected at 0,1.5,3,6and 12hafter injection.The FSHR and LHR were located in oviduct by immunohistochemistry,and expression level of FSHR and LHR were analyzed by real-time PCR and immunohistochemistry.【Results】The results shown:FSHR and LHR were located in epithelium and muscle layer of oviduct,and they were not detected in stromal layer.The transcription of FSHR and LHR in hypothalamus were not influenced by LPS,while down-regulated in oviduct.Immunohistochemistry results shown:the expression pattern of FSHR in hypothalamus and LHR in epithelium layer of oviduct may be modulated by LPS,the expression of LHR in hypothalamus and muscle layer of oviduct was down-regulated by LPS,and the expression of FSHR in epithelium and muscle layer of ovi-duct was up-regulated by LPS.【Conclusion】The fact that LPS modulates FSHR and LHR gene expression in hypothalamus indicates that this brain structure could be a place of the immune-reproductive interference and supports the thesis that immune challenges modulate the activity of animal reproduction." @default.
- W2390315322 created "2016-06-24" @default.
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- W2390315322 date "2014-01-01" @default.
- W2390315322 modified "2023-09-26" @default.
- W2390315322 title "Effect of LPS on the Expression of FSHR and LHR in Hypothalamus and Oviduct of Rabbit" @default.
- W2390315322 hasPublicationYear "2014" @default.
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