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- W2390319602 abstract "Aim To investigate the relationship between pathogenesis of atherosclerosis and nonalcoholic fatty liver disease(NFLD). Methods 64 SD rats were randomly divided into two groups: normal control group with normal basic diet and high-sucrose and high-fat diet group with high sucrose and high fat diet.Each group was divided into four phases: 3 months,6 months,9 months and 12 months.Each phase had eight rats.Alanine aminotrnsferase,free fatty acid(FFA),triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL),fasting plasm glucose(FPG),fasting insulin(FIN),and endotoxin(LPS),tumor necrosis factor-α(TNF-α),C-reaction factor(CRP),macrophagocyte chemotaxis protein-1(MCP-1),nitrc oxide(NO),endothelin-1(ET-1) were measured by ELISA;All the rats were killed and their livers and arterial specimens were taken to carry on HE stain for observing their histopathologic and morphologic change.Tunnel was used to detect the endothelial cell and smooth muscle cells apoptosis by immunohistochemistry.The expression of CD68 protein were detected by immunohistochemistry for observing mononuclear cells expression in aortic wall.Sudan IV stain was used to show whether ectopic lipid have accumulated in aortic wall.Results The level of TG,Ach,FFA,LDL,ALT,FIN,LPS,CRP,TNF-α,MCP-1,ET-1 in HSHF group was significantly increased and the level of HDL and NO was decreased(P 0.050).Three-month-old rats had nonalcoholic fatty liver disease and fatty liver,at the same time several mononuclear cells adhered to the endothelial cells some of which appeard apoptosis.Fibrosis occurred at six-months-old rats and there was lipids under the endothelial cells,meanwhile,the apoptosis exacerbated obviously.The fibrosis became gradually serious in liver in 12-month-old group.It can be observed that calcium deposited in a lot of mononuclear cells in atherosclerotic plague.Apoptosis existed in endothelial cells and smooth muscle cells.Conclusions High-fat high-sucrose diet induces non-alcoholic fatty liver disease(NAFLD),accompanied by Intestinal Endotoxemia(IETM),disturbance of lipids metabolism and chronic inflammation.IETM further results in continuous endothelial dysfunction,ectopic deposition of lipids and local infiltration of mononuclear macrophages.This finally leads to As." @default.
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- W2390319602 date "2012-01-01" @default.
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- W2390319602 title "Role of Nonalcoholic Fatty Liver Disease in the Mechanism of Atherosclerosis" @default.
- W2390319602 hasPublicationYear "2012" @default.
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