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- W2390330257 abstract "Objective: To study the effects of chronic unpredictable stress(CUS)and fluoxetine(Flu)treatment on depressive-like and anxiety-like behaviors of adult female rats.Methods: Twenty-four virgin female rats were assigned evenly to normal sodium(NS)group,fluoxetine(Flu)group,chronic unpredictable stress(CUS)exposed plus NS injection group(CUS+NS),and CUS exposed plus Flu treatement group(CUS+Flu).CUS+NS group and CUS+Flu group received a daily intraperitoneal injection of 2.5 mL/kg NS or 10 mg/kg Flu 30 minutes before CUS.NS group and Flu group only received a daily intraperitoneal injection of 2.5 mL/kg NS or 10 mg/kg Flu. The second day after the last injection,the sucrose consumption test and forced swim test were used to test the depressive-like behavior and the open field test was used to test anxiety-like behaviors.Results: There was no difference in sucrose consumption percentage,but the sucrose intake had significant difference among groups,with CUS+NS groups consuming less sucrose than all other groups.The immobility time had significant difference in 5-min swim test among groups,with CUS+NS group longer than the other three groups,and there was no difference among NS,Flu and CUS+flu groups.The central-to-total distance traveled ratio in the CUS group and the CUS+Flu group was lower than that in the NS group and Flu group,and the sum time in central part in the CUS+NS group was less than that in the Flu group,and in the CUS+Flu group was less than that in the NS group and the Flu group.Conclusion: CUS induces depressive-like and anxiety-like behavior,and flu treatment may reverse the depressive-like but not the anxiety-like behavior.Flu is devoid of mood-changing effects in normal rats." @default.
- W2390330257 created "2016-06-24" @default.
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- W2390330257 date "2010-01-01" @default.
- W2390330257 modified "2023-09-24" @default.
- W2390330257 title "Effects of Chronic Unpredictable Stress and Fluoxetine Treatment on Depressive like and Anxiety-like Behaviors of the Adult Female Rats" @default.
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