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- W2390333822 abstract "Objective To investigate the relationships of the C677T polymorphisms of the methylenetetrahydrofolate reductase(MHTFR)gene in Chinese population with migraine.Methods A total of 43 migraine with aura(MA)patients,139 migraine without aura(MO)patients(as disease controls)and 103 age-sex matched normotensive healthy controls were enrolled for our study.Genotype was determined by polymerase chain reaction and restriction fragment length polymorphism analysis.Chi-square test and t-test were applied for the analysis of the results.Results No significant differences in genotype and allelic frequencies of MTHFR C677T polymorphism were found on comparing migraine patients with healthy controls(P0.05);MHTFR mutant genotype(CT+TT)showed significant association in attack time and accompanying symptoms(P0.05)but no significance in other features of migraineurs(P0.05).Conclusion The polymorphisms of the MTHFR C677T gene were not significantly associated with migraine of Han nationality in Harbin China.MHTFR mutant genotype(CT+TT)showed significant association in attack time and accompanying symptoms but no significance in other features of migraineurs." @default.
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- W2390333822 date "2011-01-01" @default.
- W2390333822 modified "2023-09-27" @default.
- W2390333822 title "The association analysis of the MHTFR C677T gene polymorphisms with migraine" @default.
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