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- W2390344982 abstract "Objective To study the role of GNAT on treatment and prevention in postmenopausal osteoporosis female rats. Methods 60 female SD rats were divided randomly into six groups: intact (INT), sham operation (Sham), model, estrodiol (E_2), GNAT and GNAT prevention (GNAT PR) group. The bone mineral content (BMC) and the bone mineral density (BMD) of lumbar 1-6 and right thigh-bone were examined, as well as estrodiol (E_2), insulin-like growth factor Ⅰ (IGF-Ⅰ) and insulin-like growth factor binding proteins (IGF-BPs) were tested by RIA or ELISA. Results The BMC and BMD of lumbar 1-6 and right thigh-bone in model group decreased obviously, meanwhile the serum E_2, IGF-Ⅰ and IGF-BP1 reduced too. E_2 or GNAT could increase the BMD as well as upgrade the contents of E_2 and IGF-Ⅰ. However, changes were not showed in above indexes in GNAT PR group. Conclusions GNAT could improve postmenopausal osteoporosis of female rats by upgrading the serum E_2 and IGF-Ⅰ to increase BMD of postmenopausal osteoporosis rats, which provided an experimental evidence of GNAT in clinic." @default.
- W2390344982 created "2016-06-24" @default.
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- W2390344982 date "2008-01-01" @default.
- W2390344982 modified "2023-09-23" @default.
- W2390344982 title "The experimental study of GNAT on treatment and prevention in postmenopausal osteoporosis female rats" @default.
- W2390344982 hasPublicationYear "2008" @default.
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