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- W2390348233 abstract "Objective To investigate the mechanism of action of scalp cluster needling in the treatment of cerebral infarction by observing its effects on pathomorphology and apoptosis-related gene caspase-3 in rats with acute cerebral infarction. Methods Seventy-two female rats were randomly allocated to a sham-operation group(A),a model group(B) and a scalp cluster needling group(C),24 rats each.According to different times after cerebral infarction,each group was reassigned to 3 subgroups: 6 h,24 h and 3 d,8 rats in each subgroup.A animal model of acute cerebral infarction was made by a thread-occlusion method.The effects of scalp cluster needling on pathomorphology and expression of apoptosis-related gene caspase-3 in the brain tissue on the ischemic side at different times were investigated in the rats with acute cerebral infarction. Results In group B rats,complete necrosis appeared in the central zone of infarction,and the number of neurons decreased significantly and the brain tissue showed obvious edema and loose and light-stained neuropil in the peripheral zone,at 3 days after cerebral infarction.Compared with group B,glial cells proliferated and brain tissue edema abated in the peripheral zone of infarction in group C rats.At 24h to 3d after cerebral infarction,the expression of apoptosis-promoted gene caspase-3 reduced obviously in the cortex on the ischemic side in group C rats.There was a statistically significant difference compared with group B(P0.01). Conclusion Scalp cluster needling can improve neuronal function and promote neuroglial cell proliferation in the penumbra zone of cerebral infarction.It plays a certain role in cerebral protection by inhibiting the expression of apoptosis-promoted gene caspase-3." @default.
- W2390348233 created "2016-06-24" @default.
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- W2390348233 date "2008-01-01" @default.
- W2390348233 modified "2023-09-23" @default.
- W2390348233 title "Effects of Scalp Cluster needling on Pathomorphology and Apoptosis-related Gene Caspase-3 in Rats with Acute Cerebral Infarction" @default.
- W2390348233 hasPublicationYear "2008" @default.
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