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- W2390355958 abstract "Objective To examine the expressions of phosphatase and tension homologue deleted on chrom osome10(PTEN),P27 and TGF-β1 in cervical adenocarcinoma,and study their clinical significance and their correlativity.Methods Forty-three cervical adenocarcinomas were compared with 18 normal endocervical controls by immunohistochemical analysis of PTEN,P27 and TGF-β1.Results PTEN and P27 exhibited higher positive rates in cervical adenocarcinomas(62.79% and 55.81%) than those in normal endocervical controls(88.89% and 94.44%)(P0.05).The levels of PTEN or P27 expression in cervical adenocarcinomas decreased with the increasing of clinical stage(P0.01),whereas positive staining of PTEN or P27 in well-differentiated carcinoma tissues was significantly stronger than that in moderately-or poorly-differentiated carcinoma tissues.No significant difference was between the positive rate of TGF-β1 in normal endocervical controls(11.11%) and that in cervical adenocarcinomas(5.88%)(P0.05).No relationship was found between the expression of TGF-β1 in cervical adenocarcinoma and clinical or pathological features(P0.05).The expression of PTEN was positively correlated to P27 in cervical adenocarcinoma.No obvious relationship of TGF-β1 with PTEN or P27 was found.Conclusion PTEN and P27 are of value in the prognosis of cervical adenocarcinoma.TGF-β1 may not contribute to carcinogenesis and development of cervical adenocarcinoma." @default.
- W2390355958 created "2016-06-24" @default.
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- W2390355958 date "2009-01-01" @default.
- W2390355958 modified "2023-09-23" @default.
- W2390355958 title "Expressions of PTEN,P27 and TGF-β_1 in cervical adenocarcinoma and their clinical significance" @default.
- W2390355958 hasPublicationYear "2009" @default.
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