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- W2390357002 abstract "Objective To observe the changes of serum TGF-β1,liver fibrosis indexes levels and liver pathology with Entecavir(ETV)on patients with hepatic fibrosis of chronic hepatitis B.Methods A total of 32 patients with hepatic fibrosis of chronic hepatitis B were enrolled and treated with Entecavir for 48 weeks.Before and 48 weeks after treatment,the serum level of TGF-β1 was assessed by ELISA,the levels of related liver fibrosis indexes were measured by RIA,and the liver tissue was dyed with HE dyeing,Masson dyeing.Results After 48 weeks treatment with ETV,the level of serum TGF-β1was decreased significantly compared with those before(P0.05).Also,the serum liver fibrosis indexes were significantly reduced(P0.05).Liver pathology was improved after 48 week ETV treatment both in inflammation grading and fibrosis degree,the differences were significant(P0.05).Conclusion Entecavir may improve the degree of liver fibrosis in patients with chronic hepatitis B by lowering expression of serum cytokine TGF-β1." @default.
- W2390357002 created "2016-06-24" @default.
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- W2390357002 date "2015-01-01" @default.
- W2390357002 modified "2023-09-24" @default.
- W2390357002 title "Effect of entecavir on serum TGF-β_1,liver fibrosis indexes levels and liver pathology in patients with hepatic fibrosis of chronic hepatitis B" @default.
- W2390357002 hasPublicationYear "2015" @default.
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