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- W2390368127 abstract "PURPOSE: To illustrate the relationship between TGF-β1/MAPKs/MMPs signaling pathway and microRNA(miRNA) expression, and to explore the potential role of miRNA in the metastasis of salivary adenoid cystic carcinoma(SACC). METHODS: MiRNA array was performed to analyse the changes of miRNA expression inSACC cells before or after TGF-β1 stimulation, and then several significant different microRNAs were selected to be verified by qRT-PCR assay. Meanwhile, their target genes were predicted by miRNA target gene prediction programs. RESULTS: MicroRNA microassay showed that SACC_LM_neg/SACC_83_neg: up 40, down 101.One of them was up-regulated and twelve miRNAs of them were down-regulated after treated by TGF-β1 which were accordant with the results of qRT-PCR assay. MiR-125a-5p, miR-181 d, mir-145-3p, mir-126-3p and mir-320 d were chosen and several genes were predicted as targets of these differently regulated miRNAs related to TGF-β1/MAPKs/MMPs signaling pathway. CONCLUSION:There are differentially expressed microRNAs between SACC-LM and SACC-83. TGF-β1 can affect miRNAs profiling of SACC. MiR-125a-5p, miR-181 d, mir-145-3p, mir-126-3p and mir-320 d may be regulated by TGF-β1/MAPKs/MMPs signaling pathway." @default.
- W2390368127 created "2016-06-24" @default.
- W2390368127 creator A5049462998 @default.
- W2390368127 date "2014-01-01" @default.
- W2390368127 modified "2023-09-28" @default.
- W2390368127 title "TGF-β1 signaling pathway related microRNA regulates metastasis of salivary adenoid cystic carcinoma" @default.
- W2390368127 hasPublicationYear "2014" @default.
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