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- W2390372012 abstract "This study aims to investigate the expressions and the correlation of DR5 and bcl-2 protein in HeLa and human cervical carcinoma.The flow cytometry was used to detect the expressions of DR5 in the surface of HeLa;and the immunohistochemical technique was used to detect the expressions of DR5 and bcl-2 protein in 76 cases of cervical carcinoma,30 cases of cervical intraepithelial neoplasia(CIN) and 20 cases of normal cervix.The correlation between the expressions obtained from these two methods was analyzed.The expression rates of DR5 in the surface of HeLa were 30%.The expressions of DR5 and bcl-2 protein were mainly detected in the cell of CIN and cervical carcinoma.And the positive expression rate of DR5 in cervical squamous cell carcinoma(66%) was higher than those in adenocarcinoma(62%,P 0.05),CIN(40%,P 0.05),and normal cervical epithelium(35%,P 0.05).At the same time,the differences between the expression amount in CIN and normal cervical epithelium had no statistical significance(P 0.05).The positive expression rates of bcl-2 in squamous-cell carcinoma,adenocarcinoma,CIN,and normal cervical epithelium were 70%,65%,50% and 20%,respectively.Thus,we can conclude that the expressions of DR5 were positively correlated with bcl-2 expression in cervical carcinoma(χ2 = 10.75,P = 0.000);and the expression of DR5 protein has certain relations with the occurrence and development of human cervical carcinoma." @default.
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- W2390372012 date "2011-01-01" @default.
- W2390372012 modified "2023-09-23" @default.
- W2390372012 title "Expression and correlation of DR5 and bcl-2 protein in HeLa and cervical carcinoma" @default.
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