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- W2390385663 endingPage "321" @default.
- W2390385663 startingPage "295" @default.
- W2390385663 abstract "Repeated failure in neurodegenerative disorder (NDD) treatment has resulted in some real diminution in the level of interest in future drug discovery efforts. As this chapter shows, failure is a continuing and vexing problem but must be considered part of the drug discovery and development process, as it always has been. One approach that may prove useful for the development of stand-alone therapeutics or components of combination therapies is to target dysfunctional mitochondria. The chapter focuses on a recent effort, a small-molecule mitochondrial modulator for amyotrophic lateral sclerosis (ALS). Mitochondrial dysfunction has been implicated in many NDDs, and that targeting mitochondria represents a rich, relatively recent hunting ground for the development of new therapies. The example in the chapter illustrates a mitochondrial approach. The development of dexpramipexole (DEX) for the treatment of ALS illustrates the logic of the approach." @default.
- W2390385663 created "2016-06-24" @default.
- W2390385663 creator A5008615465 @default.
- W2390385663 date "2015-09-25" @default.
- W2390385663 modified "2023-09-27" @default.
- W2390385663 title "Neuronal Mitochondria as a Target for the Discovery and Development of New Therapeutics" @default.
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