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- W2390390795 abstract "Objective:To study the balanced regulation of Juanbi Granule on Th17/Treg cells in mice with collagen-induced arthritis in order to explore its mechanism in the treatment of rheumatoid arthritis. Methods:The arthritis models were induced by the bovine type II collagen.20 DBA/1 mice were divided equally into the CIA group and the Juanbi granule group according to the clinical score.The arthritis clinical score method was used to observe the seriousness of the onset of arthritis in CIA mice;the flow cytometry was used to detect the subpopulation of the splenic lymphocytes(CD4,CD8,B220),and the Th17,Th1 cytokines and the expression of Treg cells in CD4+T cells.Results:Juanbi Granule could significantly reduce the clinical score of CIA mice with collagen-induced arthritis,but had no significant effect on the subpopulation of the splenic lymphocytes(CD4,CD8,B220).Meanwhile,it down regulated the expression level of IL-17A in the CD4+T cells of CIA mice,promoting the expression of Treg cells in a certain extent. Conclusion:Regulating the balance of the Th17 cells and Treg cells and down-regulating the expression of the proinflammatory cytokine IL-17A may be one of its mechanisms in the treatment of rheumatoid arthritis." @default.
- W2390390795 created "2016-06-24" @default.
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- W2390390795 date "2014-01-01" @default.
- W2390390795 modified "2023-09-25" @default.
- W2390390795 title "Study on the Balanced Regulation of Juanbi Granule on Th17/Treg Cells in Mice with Collagen-induced Arthritis" @default.
- W2390390795 hasPublicationYear "2014" @default.
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