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- W2390400741 abstract "Objective To investigate the solubility enhancement of solid dispersions prepared by cogrinding method .Methods A coground mixture and solid dispersions of lipophilic extract from Indigo were prepared with water-soluble polymer. An HPLC method was established for the determination of indirubin to study the solubilities of the solid system with indirubin as a reference substance. Results The results showed that the solubility of indirubin in solid dispersions prepared by cogrinding method were remarkably enhanced as well as coevaporation method.It was suggested that hydroxyl group in series of water-soluble polymers plays a key part in the solubility enhancement from the result of the effect of polymer species in the coground mixture on indirubin solubility .Conclusion The present cogrinding method is very effective for improvement of solubility of poorly water-soluble drugs." @default.
- W2390400741 created "2016-06-24" @default.
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- W2390400741 date "2007-01-01" @default.
- W2390400741 modified "2023-09-25" @default.
- W2390400741 title "Preparation and Solubility Charaterization of Lipophilic Indigo Extracts′ Solid Dispersions" @default.
- W2390400741 hasPublicationYear "2007" @default.
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