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- W2390410017 abstract "[Purpose]To investigate expression of p53 protein in gastric cancer cells and itsrelationship with prognosis. [Methods]Immunohistochem icaltechnique was used to detectexpressionofp53 protein in 131 cases with antralgastric cancer. The relationship between expression ofp53protein and clinicopathologicalfactors and with long-term effectin antral gastric cancer after radicalsurgery were analyzed.[Results]The positive rate ofp53 protein was 42% (55/131) in gastric cancertissue. There was no significantcorrelation ofp53 protein expression with gender, age, course ofdisease, Borrm ann and histologicaltype oftum or (P0.05), buta significantpositive correlation withtum orinvasive depth to walland m etastasis oflym ph nodes(P0.05).Overall5-,and 10-yearsurvivalrate afterradicalsurgery were 53.6% and 45.9% respectively.Fornegative p53 group,5-,and 10-yearsurvivalrate were 61.1% and 49.7% respectively with a m edian survivalof 107.8 months; and forpositive p53 protein group,42% and 42% respectively with a m edian survivalof35.3 m onths. Therewas significant difference between patients with negative and positive p53 protein (P =0.006).[Conlusion]p53 protein expression has a significant correlation with tumor invasion and lym phaticm etastasis in gastric cancer, and it is a poor prognostic predictor for gastric cancer after radicalsurgery." @default.
- W2390410017 created "2016-06-24" @default.
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- W2390410017 date "2005-01-01" @default.
- W2390410017 modified "2023-09-25" @default.
- W2390410017 title "Relationship between Long-term Effect and Expression of p53 Protein in Antral Gastric Cancer after Redical Surgery" @default.
- W2390410017 hasPublicationYear "2005" @default.
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