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- W2390412528 abstract "Objective To study the antiarrhythmic effect of phenolated alkaloids.Methods The arrhythmic animal models were respectively performed by ouabain(guinea pigs),CaCl2 and aconitine(rats) and trichloromethane(mice).The treatment groups were given the phenolated alkaloid and the control group gained only normal saline.Make a comparison among the arrhythmic pictures in all groups.Results Phenolated alkaloids could markedly increase the threshold dosage of ventricular extrasystole,ventricular fibrillation(VF) and cardiac arrest(CA) caused by ouabain in guinea pigs or by aconitine in rats;delay the occurance of arrhythmia and shorten its recovering time and decrease the mortality of CA caused by CaCl2 in rats;reduce the ratio and delay the occurance of VF caused by trichloromethane in mice(comparing with positive drags,P0.01).Conclusion Phenolated alkaloids have a conspicuous antiarrhythmic effects,the mechanism may be related to inhibition the inflow of Na+ and Ca2+ into the myocardial cell." @default.
- W2390412528 created "2016-06-24" @default.
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- W2390412528 date "2007-01-01" @default.
- W2390412528 modified "2023-09-26" @default.
- W2390412528 title "Antiarrhythmic Effect of Phenolated Alkaloids in Plumula Nelumbinis" @default.
- W2390412528 hasPublicationYear "2007" @default.
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