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- W2390434440 abstract "Objective:To establish a reliable portal hypertension rat model with cirrhosis.Materials and methods:Fifty male SDrats were randomly divided into three groups:group A,B and control group.The left adrenal vein of group A(n=20) was ligated bofore receiving continuous administration of thioacetamide(TAA) in the drinking water.And the concentration d TAA was adjusted according to weekly weight changes of the rats,with the initial concentration 0.03%.Group B(n=20) was given sham operation with the fixed concentration of TAA 0. 03%.The control group (n=10) was accepted sham operation and was supplied with normal water.Results:The mortality in group B was 15% and the rate of cirrhosis formed was only 75%.In contrast,there was no death and cirrhosis formed was 100% of the rats in group A.The portal venous pressure of the rats in group A was higher than that of group B and the control group.Conclusions:The method of combining ligation of the left adrenal vein with adjustment of concentration of TAA in the drinking water according to weight changes of the rats can establish a reliable rat model of portal hypertension with cirrhosis." @default.
- W2390434440 created "2016-06-24" @default.
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- W2390434440 date "2006-01-01" @default.
- W2390434440 modified "2023-09-23" @default.
- W2390434440 title "Investigation of modeling portal hypertension rats with cirrhosis" @default.
- W2390434440 hasPublicationYear "2006" @default.
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