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- W2390445767 abstract "Objective To study the cartilage differentiation of rabbit messenchymal stem cells (MSCs) induced by bone morphogenetic protein (BMP).Methods The MSCs were separated and cultured from rabbit thighbone marrow.Growth kinetics was studied by growth curve.The MSCs had been cultured in the BMP medium for 10 days,and then the ALP activity was observed.The induced MSCs/PGA was implanted in the nude mice subcutaneously.The implants underwent the histological analysis after 2 months.Results The MSCs were successfully cultured and induced by the BMP.The growth curve showed that the time of population doubling was 3.0 days.ALP activity was 0.282± 0.015, 0.502± 0.012 in BMP group and 0.265± 0.010, 0.315± 0.021 in control group respectively after induction for 5 and 10 days (P 0.01).The cells displayed fibroblast-like morphology.Histological evaluation showed the cartilage formation in 2 months in vivo.[WT5”HZ]Conclusion BMP can induce MSCs to differentiate chondral cells,and MSCs have the capability to generate cartilage." @default.
- W2390445767 created "2016-06-24" @default.
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- W2390445767 date "2005-01-01" @default.
- W2390445767 modified "2023-09-24" @default.
- W2390445767 title "Cartilage differentiation of rabbit messenchymal stem cells induced by bone morphogenetic protein" @default.
- W2390445767 hasPublicationYear "2005" @default.
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