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- W2390457788 abstract "Objective To investigate the significance of IκB kinase-β(IKK-β) and the protective effect of Ligustrazini(Lig) in acute lung injury(ALI) induced by hemorrhagic shock(HS) in rabbits. Methods Thirty rabbits were randomly divided into three groups: HS plus endotoxin group(n=10), Lig treatment group(n=10) and the normal group(n=10). In situ hybridization and immunohitochemistry combined with in situ quantitative analysis were used to detect the distribution and relative contents of IKK-β and NF-κB in lung tissues. The plasma concentration of tumor necrosis factor-α(TNF-α) was measured by ELISA. Morphological change of the lung was observed by light microscopy. Results Compared with the normal group, the expression levels of IKK-β(0.223±0.080), NF-κB(0.162±0.021), and TNF-α(809.33±201.6) were obviously increased in HS plus endotoxin group(P0.05). Lig treatment could inhibit the expression of IKK-β(0.163±0.066) and NF-κB(0.120±0.020), decrease the plasma concentration of TNF-α(447.50±100.80)and alleviate the lung injury. Conclusion IKK-β/NF-κB/TNF-α may play a crucial role in the pathogenesis of ALI induced by HS. Lig could down-regulate the activity of IKK-β/ NF-κB pathway, and relieve HS-induced ALI." @default.
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- W2390457788 date "2005-01-01" @default.
- W2390457788 modified "2023-09-26" @default.
- W2390457788 title "The Effect of Ligustrazini on IκB Kinase-β Expression in Acute Lung Injury Induced by Hemorrhagic Shock in Rabbits" @default.
- W2390457788 hasPublicationYear "2005" @default.
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