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- W2390460756 abstract "Objective Dosimetric analysis was carried to investigate the patterns of local failure for patients with highgrade gliomas after three dimensional conformal radiotherapy(3DCRT),to explore the more feasible delineation of clinical target volume and increase the local control rate.Methods 11 patients with local relapse were performed.The region of tumor recurrence was contoured and entered into the treatment planning system.The rGTVs(relapsed gross tumor volumes) were drawn without the aid of the original treatment plan to avoid bias.Failure patterns were defined in terms of percentage of recurrent tumor located within the high-dose region.Recurrences with more than 95% of their volume within the high-dose region were considered central;those with 20% to 95% and less than 20% were considered marginal and distant,respectively.Results 12 rGTVs were drawn in 11 patients because one patient performed 2 unconnected volumes.The patterns of failure were 4(33%) of 12 central,1(8.3%) of 12 marginal,7(58.3%) of 12 distant.Recurrent tumors in ventricles of brain were performed in 6 patients.The dose of geometric center of 7 distant volumes were 16.40-64.31 Gy,median 49.29 Gy.The distance between geometric center and high-dose region were 0.45-2.63 cm,median 2.24 cm.The distance between geometric center and the initial GTV were 0.94-4.60 cm,median 2.75 cm.Conclusion The ratio of distant recurrences indicates that delineation of clinical target volume is NOT feasible and deserves further evaluation for high-grade gliomas.For patients with initial tumor invaded ventricles of brain,to define the ipsilateral lateral ventricle of brain as clinical target volume is suggested." @default.
- W2390460756 created "2016-06-24" @default.
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- W2390460756 date "2010-01-01" @default.
- W2390460756 modified "2023-09-28" @default.
- W2390460756 title "Patterns of Failure Following 3-D Conformal Radiotherapy for High-grade Gliomas" @default.
- W2390460756 hasPublicationYear "2010" @default.
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