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- W2390465013 abstract "Purpose To explore the altered concentrations of 8 hydroxy 2′ deoxyguanosine(8?OH dG) in cerebral genome of aging rats and regulative effect of Zuogui Wan(ZGW) on it. Methods Aging rat mo dels were established by being fed for 24 months and randomly divided into two groups,aging group and ZGW group by three month administration of 0.9% NS and ZGW liquid respectively,and controlled by young group which consisted of three month old rats.Cerebral samples were harvested from rat brain of every group and the levels of 8?OH dG was assessed by enzyme linked immunosorbent assay(ELISA). Results The levels of 8?OH dG in cerebral genome of aging rats were higher than the young control while decreased after ZGW administration. Conclusions It is suggested that the upregulated contents of 8?OH dG in genome of aging neocortex may be related to agravating brain senescence and contributing to neural degenerative desease.ZGW has effect of neural protection and repairment on brain through down regulating genomic 8?OH dG." @default.
- W2390465013 created "2016-06-24" @default.
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- W2390465013 date "2002-01-01" @default.
- W2390465013 modified "2023-09-25" @default.
- W2390465013 title "Effect of Zuogui Wan on 8-hydroxy-2′-deoxyguanosine of Neocortex of Aging Rats" @default.
- W2390465013 hasPublicationYear "2002" @default.
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